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Featuring articles on PD-1 blockade in locally advanced rectal cancer, a vaccine against respiratory syncytial virus, a vitamin C infusion in adults with sepsis, and reducing administrative harm in medicine; a review article on Philadelphia chromosome–positive acute lymphoblastic leukemia; a case report of a woman with jaundice and chronic diarrhea; and Perspective articles on racial disparity in breast-cancer mortality, on enrollee premiums in Medicaid, on a data infrastructure for clinical trial diversity, on medicalizing the Constitution, and on unexpected closure.