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Featuring articles on KRAS inhibition in non–small-cell lung cancers with a KRAS mutation, resistance to KRAS inhibition, adjuvant olaparib in BRCA1/2-mutant breast cancer, a genetic deficit in the cellular sanitation system, and the treatment of rectal chlamydia; a review article on stress incontinence in women; a case report of a man with irritability, confusion, and odd behaviors; and Perspective articles on health equity and Medicaid transformation, on pregnant women with substance use disorders, and on combating anti-Asian sentiment.