Why do my urinary B6 markers say I'm deficient if I'm supplementing and my plasma levels are high-normal? | Masterjohn Q&A Files #300
Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake.
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This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:
- How do I know if my digestive enzymes are helping or hurting?
- Why does high-dose glycine give me these terrible symptoms?
- How to know if my magnesium is messing with my calcium?
- Why do I have vitamin A symptoms when my lab tests are normal
- What is my favorite web site for finding enzymatic cofactors
- Potassium citrate vs potassium chloride
- Major problems with B vitamin supplements
- Is food sensitivity testing useful?
- What nutrients might help with dihydropyrimidine dehydrogenase deficiency?
- Does lipoic acid hurt methylation?
- Sulfur SIBO that just won’t go away.
- Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio.
- Helping bile flow without pharmaceuticals.
- Managing pernicious anemia.
- Do we really need to meet the RDA for calcium?
- Could stretch marks be a sign of copper toxicity?
- When iron saturation is driven by low binding capacity.
- How do I know if I need methyl-free Bs?
- What causes heat intolerance?
Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3
Access the show notes, transcript, and comments here.