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What are the three biggest changes to the Guideline for Medication Safety? It all depends on your facility, but labeling, hazardous medication and antibiotic oversight were three issues that really stood out to guideline author Julie Cahn, sr. perioperative practice specialist at AORN. Medication errors are preventable but continue to occur despite regulations, governmental resources and oversight, recommendations from professional organizations, and accreditation body standards. Elimination of medication errors is important because these errors can cause patient harm, reduced patient confidence in the health care system, and increased costs.