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For Dr. Steve Holland, the mystery of why some people are more prone to disease is as much a curiosity as it is a calling. Dr. Holland is the scientific director and chief of the immunopathogenesis section at the National Institute of Allergy and Infectious Diseases (NIAID) where he searches for signs to explain differences in susceptibility to certain infections. In this episode, he discusses how the immune system can thwart its own defenses by producing antibodies that block the chemical signals it needs to put up a fight.