NEJM This Week — April 7, 2022

Featuring articles on endovascular therapy for large cerebral infarction, population immunity and Covid-19 severity with the omicron variant in South Africa, tebipenem for complicated urinary tract infection, an implanted stimulator in multiple-system atrophy, U.S. medical faculty diversity over four decades, and the origins of calcific aortic stenosis; a review article on the laboratory diagnosis of Creutzfeldt–Jakob disease; a Clinical Problem-Solving describing a burning question; and Perspective articles on ten years of Choosing Wisely to reduce low-value care, on putting health and equity at the center of the climate movement, and on the wild west of checkpoint inhibitor development.

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