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Practice Bulletin #84 - Published August 2007 (Reaffirmed 2018) 1. Most patients who die from PE do so within 30 minutes of the event, so prevention is key. 2. If a patient is known to have Factor V Leiden mutation or prothrombin gene mutation 20210A, they should be considered high risk and managed appropriately intra- and post-operatively and in pregnancy 3. Compression stockings, pneumatic compression devices, and pharmacologic prophylaxis are all safe and useful in preventing VTE 4. Highest risk patients benefit most from a combined approach of mechanical or stocking prophylaxis combined with pharmacologic prophylaxis 5. Platelet inhibitors should be stopped 14 days before spinal or epidural anesthesia, unfractionated heparin or twice daily low molecular weight heparin 8-12 hours before, and low molecular weight heparin 18 hours before  Show Notes Wine pairing: 2019 Les Quatre Cepages from Domaine de Pajot Theme music by Evan Handyside Logo design by JD Dotson (jddotson1@gmail.com)