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Featuring articles on osimertinib in stage III EGFR-mutated lung cancer, cognitive motor dissociation in disorders of consciousness, rapid deployment of a brain–computer interface in ALS, and the longevity of a brain–computer interface for ALS; a review article on the genetics of chronic kidney disease; a case report of a boy with autism and decreased vision; and Perspectives on medical expertise, on collecting data on sexual orientation and gender identity, and on the pursuit of polka dots.