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High homocysteine levels are associated with cardiovascular disease and dementia. A series of studies have shown that the relationship with cardiovascular disease is not causal [1,2]. However, yet another series of randomized controlled trials have shown that reducing homocysteine levels reduces brain atrophy and cognitive decline [3,4,5], as well as risk of stroke [6] and symptom severity in schizophrenia [7,8]. Yet other studies suggest still other benefits for psychiatric disorders such as bipolar disorder [9]. This podcast explores the risks and benefits of homocysteine reduction by the use of three vitamins: B12, B6, and folate, as well as what might be the recommended dose for this purpose [10].

References (PMIDs):

[1] 16450017

[2] 16531614

[3] 20838622

[4] 23690582

[5] 25877495

[6] 19228852

[7] 23467813

[8] 16412989

[9] 35386526

[10] 31677936

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