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Vitamin D supplements have been widely touted as a cure-all based on weak observational evidence and animal data. Unfortunately, these data have not been well-supported by the randomized controlled trial data. In this episode, we examine a potential harm of vitamin D supplements within the normal range of supplementation: bone mineral density loss. In a study published in the Journal of the American Medical Association, there was a dose-response relationship between vitamin D supplementation and bone mineral density loss, with increasing loss seen at 4,000 IU and 10,000 IU (PMID 31454046). If you are at risk for osteoporosis and want to take vitamin D supplements, please talk with you doctor, as these data indicate that high-dose vitamin D supplements may enhance risk for the disease.

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