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Featuring articles on neoadjuvant chemoimmunotherapy in resectable non–small-cell lung cancer, tranexamic acid for noncardiac surgery, activation of oncogene expression by demethylating agents, efficacy of the mRNA-1273 vaccine in older children, and structural racism in the academic residency clinic; a review article on the gliflozins in the management of cardiovascular disease; a case report of a man with fevers, night sweats, and a mediastinal mass; and Perspective articles on federal action supporting overdose-prevention centers, on when naloxone isn’t enough, and on e pluribus unum.