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Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.