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Featuring articles on circulating tumor DNA and adjuvant therapy in colon cancer, the prevention of anal cancer, Chapare hemorrhagic fever in Bolivia, immune tolerance after sequential stem-cell and kidney transplantation, and potentiating the T cell; a review article on climate change, fossil-fuel pollution, and children’s health; a case report of a woman with recurrent fractures; and Perspective articles on research to move policy, on climate change in the Supreme Court, and on medical readers and literary plague.