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This episode is a recording of the 06/25/2016 Facebook Live event, "Ask Chris Masterjohn, PhD, Anything About Methylation." Among the questions answered and topics discussed in this episode are the following: An MTHFR mutation (e.g. C677T) even with normal homocysteine could mean that you are taxing your choline supply and wasting glycine into your urine. Boosting choline and glycine intake could help. What may surprise you is that so could supplementing with creatine! How to implement the above strategies with natural foods? Can targeted SAMe supplementation be useful for diagnosing methylation problems? Choline and fatty liver disease. Why is my serum B12 soaring through the roof when I haven't even been supplementing? COMT mutations regulating the balance between mental stability and mental flexibility via dopamine, and whether supplementing with 5-methylfolate could worsen mental problems in people with high COMT activity. Potential relations to obssessive compulsive disorder (OCD) and to post-traumatic stress disorder (PTSD). How should you get choline if you're allergic to eggs? With an MTHFR mutation and high liver enzymes, choline would seem to be in order, but should you also rethink your high-fat diet? All this and more!