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This week's View includes discussion of the comparative safety and effectiveness of apixaban versus rivaroxaban for patients with nonvalvular atrial fibrillation, the early and late outcomes between redo surgical aortic valve replacement and valve-in-valve transcatheter aortic valve replacement for failed biological prostheses, and predictive value of a multimarker panel for risk of death and hospitalization for patients with heart failure with preserved ejection fraction.