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Featuring articles on the duration of adjuvant therapy in breast cancer, tofacitinib for Covid-19 pneumonia, complications in youth-onset type 2 diabetes, a small-molecule SMN2 modifier in type 1 spinal muscular atrophy, a hyperimmune globulin to prevent congenital cytomegalovirus, and scarless wound healing; a review article on depression in adolescents; a case report of a woman with bloody stools and thrombocytopenia; and Perspective articles on from crime to care, on health care budgets for rural providers, on identifying and tracking SARS-CoV-2 variants, and on a child’s loss.