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Featuring articles on interrupting therapy to attempt pregnancy after breast cancer, trifluridine–tipiracil and bevacizumab in colorectal cancer, imaging- or angiography-guided PCI for complex lesions, and idiopathic CD4 lymphocytopenia; a review article on neonatal seizures; a Clinical Problem-Solving describing a diagnostic sequence; and Perspective articles on combating West Nile virus disease, on falling insulin prices, on next steps in policy reforms to address the overdose crisis, and on the breast biopsy and the Buddhist half-smile.