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Here is a summary of this episode: The 5-HT1A receptor is responsible for passive coping with stress, anxiolytic, anti-anxiety and anti-aggression effects. The 5-HT2A receptor is responsible for more active coping, cognitive flexibility, and creative thinking. The 5-HT2A receptor is the most abundant serotonin receptor in the cortex and is particularly found in the prefrontal, cingulate, and posterior cingulate cortex. Download a PDF of this interview here Become a premium member of the Psychopharmacology Institute