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Today’s question is: How to manage the comorbidities of PTSD? Here is a summary of this episode: Screen for substance use and avoid prescription drugs like benzodiazepines. Desipramine and topiramate might help with comorbid alcohol use disorder. In PTSD-related psychosis, try an SSRI first. If that doesn’t help, add a second-generation antipsychotic like risperidone. Prescribe paroxetine with caution in women of childbearing potential. Download a PDF of this interview here Become a premium member of the Psychopharmacology Institute