Episode 77.0 – Give TXA Now!
This week the podcast features a talk Jenny Beck-Esmay gave at the 11th All NYC EM Conference entitled "Give TXA Now!"
Show Notes
Take Home Points
- Giving TXA provides a significant mortality benefit to the any trauma patient requiring massive transfusion with an NNT = 7 for mortality
- TXA must be given early. Give within 1 hour of injury if possible but the benefit remains up to 3 hours out
- TXA administration: 1 gram as a bolus followed by 1 gram over the next 8 hours
Show Notes
Intensive Care Network: Karim Brohi on TXA in Trauma
EMCrit: Podcast 67 – Tranexamic Acid (TXA)
Core EM: CRASH-2 Tranexamic Acid in Major Trauma
References
CRASH-2 trial collaborators. Effects of tanexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a ransomised placebo-controlled trial. Lancet 2010; 376: 23-32.
