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Harry welcomes back Andrew A. Radin, CEO of the drug discovery startup twoXAR, where scientists model pathogenesis computationally to identify potential drug molecules, ideally shaving years off the drug development process.

Harry first spoke with Radin two years ago at the AI Applications Summit—Biopharma. (Listen back to MoneyBall Medicine Episode 9 from November 2018 for more details about the company's innovations.) Since then, the company has begun to use what Radin calls twoXAR's "discovery engine" to test hypotheses about new drug leads in 18 different treatment areas, counting a dozen internal programs.

"We go after complex disease where we think there is not only an unmet medical need, but where we believe discovery of new biology can  unlock some opportunity for new therapy," Radin tells Harry. He says the company's approach compresses the time-consuming early steps of basic science, literature search,  hypothesis formulation, and high-throughput screening into a single computational step. "We're going to take all the existing knowledge about the disease and set it aside and see if we can't make some new discoveries about the biology as the starting point."

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Transcript

Harry: Andrew welcome back to the show. 

Andrew: It's great to be here. I think it's, it's been about two years since we, yeah, I was, 

Harry: I went back. I was looking at, I was like, when, when did we record the last show? I'm like, Oh my, two years. And two years in the world of data is like, 

Andrew: I don't know from the technology perspective, we've actually, let's see, in those two years, we've probably made about a hundred new releases, new iterations of our software over that time.

And so imagine, imagine like, you know, getting a hundred new versions of your car and of course technology just moves that fast. 

Harry: Yeah, no, I, it's funny because I have this conversation with people regularly of like, you know, Well, you know, is this software done? I'm like, listen, it's software. It's never done. Right? 

Andrew: Yeah. And so while it, it, it certainly depends. I think on how the software is deployed. I mean, there's, um, you know, as a guys built a lot of software system