NEJM This Week — December 23, 2021

Featuring articles on the effects of a Covid-19 vaccine booster, spesolimab for generalized pustular psoriasis, decentralized molecular testing for tuberculosis, and consultative medicine; a review article on immune and genome engineering as the future of transplantable tissue; a case report of a woman with respiratory failure and altered mental status; and Perspective articles on clinical care and Amazon, on Covid-19 vaccination in American Indians and Alaska Natives, on tobacco-free nicotine, and on a divisive ruling on devices.

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