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In this episode I welcome on one of my hero's in medicine, Dr. Mark Pimentel.   Without hesitation, he changed my career trajectory for the better when I first came across his work in 2007. Since then he has been a mentor, adviser, and educator of me as I have dedicated myself to helping patients dealing with Irritable Bowel syndrome, Small Intestinal Bacterial Overgrowth, and Intestinal Methanogen Overgrowth.

We covered so many amazing topics in this episode including:

• Highlights from the last 5 years of Dr. Pimentel's research
• His career trajectory from IBS starting as a psychosomatic disorder to know a disorder with a defined pathophysiology\
• The latest 2021-22 research that identified the key microbes involved with hydrogen overgrowth sibo, intestinal methanogen overgrowth, and hydrogen sulfide overgrowth
• The role of bile acids in Irritable bowel syndrome
• The role of stomach acid in IBS/SIBO/IMO
• The role of the migrating motor complex in IBS
• Post-infectious Irritable bowel syndrome
• What makes a good GI Doctor
• the Medically Associated Science and Technology Program (MAST) at Cedar Sinai
• and more.

about Dr. Pimentel:

Mark Pimentel, MD, FRCP (Fellows of the Royal College of Physicians – Canada) Mark Pimentel, MD, is a Professor of Medicine at Cedars-Sinai. Dr. Pimentel is also the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai, an enterprise of physicians and researchers dedicated to the study of the gut microbiome in order to develop effective diagnostic tools and therapies to improve patient care. Dr. Pimentel is also a Professor of Medicine at the Geffen School of Medicine, University of California, Los Angeles (UCLA.) As a physician and researcher, Dr. Pimentel has served as a principal investigator or co-investigator for numerous basic science, translational and clinical investigations of irritable bowel syndrome (IBS) and the relationship between gut flora composition and human disease. This research led to the first ever blood tests for IBS, ibs-smart™, the only licensed and patented serologic diagnostic for irritable bowel syndrome. The test measures the levels of two validated IBS biomarkers, anti-CdtB and anti-vinculin. A pioneering expert in IBS, Dr. Pimentel’s work has been published in the New England Journal of Medicine, Annals of Internal Medicine, American Journal of Physiology, American Journal of Medicine, American Journal of Gastroenterology and Digestive Diseases and Sciences, among others. Dr. Pimentel has presented at national and international medical conferences and advisory boards. He is a diplomate of the American Board of Internal Medicine (Gastroenterology,) a fellow of the Royal College of Physicians and Surgeons of Canada and a member of the American Gastroenterological Association, the American College of Gastroenterology, and the American Neurogastroenterology and Motility Society. Dr. Pimentel completed 3 years of an undergraduate degree in honors microbiology and biochemistry at the University of Manitoba, Canada. This was followed by his medical degree, and his BSc (Med) from the University of Manitoba Health Sciences Center in Winnipeg, Manitoba, Canada, where he also completed a residency in internal medicine. His medical training includes a fellowship in gastroenterology at the UCLA Affiliated Training Program.

papers referenced

https://journals.lww.com/ajg/pages/articleviewer.aspx?year=2022&issue=12000&article=00029&type=Fulltext

https://pubmed.ncbi.nlm.nih.gov/33534012/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145321/

#ibs #sibo #imo #irritablebowelsyndrome #dysbiosis